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There are several limitations of the current study

Chronic pain, autoimmune diseases, anxiety and depression are more prevalent in women especially during reproductive age probably due to increased negative life events, sensitivity of adrenal cortex and the influence of steroid hormones such as estradiol as well as progesterone[30-32]

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Cellular Adaptation and fibrosis Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury

Oral copper supplementation is an effective way to treat deficiency: the recommended dose is 1.53 mg once or twice a day for 3 months