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As mentioned, one of the key molecular hallmarks of AD is the A plaques, which form as a result of the abnormal processing of amyloid precursor protein (APP)

Thus a family of metabolically stabile Ang IV-related analogs has been developed in our laboratory, which are referred to here as the 6-AH family because of 6-amnio hexanoic amide substituted at the C-terminal position

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Axon degeneration Several studies in humans and animals have demonstrated axon degeneration after long-term administration of chemotherapeutic agents, including the loss of large myelinated, small unmyelinated (more rarely), and intra-epidermal nerve fibers (IENF) which may be connected to the development of sensory-motoric peripheral neuropathy (Bradley et al., 1970

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