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Studies on Mn deficiency in humans and animals have demonstrated its essential role in reproduction, skeletal development, lipid metabolism, blood clotting, and blood glucose regulation (Powers et al., 2023

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The other key indicator of ferroptosis is an increase in the levels of MDA, the final product of lipid oxidation (114)

In the event of GLS or ASNS inhibition, compensatory mechanisms may emerge, potentially accounting for the diminished anticancer efficacy observed in GLS targeting

U50,488 and dynorphin A (1-17), but neither etorphine nor levorphanol, promote a time-, and concentration-dependent internalization of hKOR (Li et al., 2003)

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