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A recent study further demonstrated that oral administration of auraptene alleviated myocardial hypertrophy and enhanced contractile function in rats with MI by activating PPAR -associated genes (Sunagawa et al., 2022)

Genetic variants associated with uric acid levels mainly include purine metabolism (e.g., XDH, HPRT1), urate transporters (e.g., SLC2A9, SLC22A12), and renal urate processing regulators (e.g., ABCG2)