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Possessing stem-like properties, tumor-repopulating cells (TRCs) develop therapeutic resistance to both chemotherapy and irradiation through mechanisms that reduce their susceptibility to ferroptotic cell death (81)

So far, surgical resection is still a state-of-the-art technique used as a classic process to model liver injury, with the hepatic resection model being the most common mouse animal model mimicking acute liver injury, while another, the ischemic ligation devascularization model, has also been used in some studies as a more conservative alternative (Table 1)

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It is therefore conceivable that multiple mechanisms are involved in CDDP resistance, including reduction of drug transport and increased DNA adduct tolerance and repair [9, 10]

"Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair." Nature

While peptides are generally less immunogenic than larger proteins, they can still trigger antibody formation in some patients