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The paradigm of systemic therapy has shifted from traditional methods to subtype-specific and personalized approaches (Fig

Additionally, aspartate is involved in energy metabolism as an intermediate in the tricarboxylic acid (TCA) cycle, and its availability can support increased metabolic demands during stress responses [46]

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Selection among these quantitative approaches depends on experimental design, sample characteristics, required analytical depth, and quantitative precision needs

Moderate alcohol consumption, defined as up to one drink per day for women and up to two drinks per day for men, is generally considered acceptable for most patients, though individual tolerance and circumstances should be considered