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Ethics declarations Ethics approval and consent to participate The research is conducted under the supervision of Research Ethics Committee of the University of Tokyo, Japan

Overall, therapeutic interventions targeting amino acid metabolism may provide novel biomarkers and treatment strategies for autoimmune-related diseases, but their clinical translation still depends on higher-resolution human validation and mechanism-oriented precision studies

Mitochondrial DNA mutations distinguish bilateral multifocal renal Oncocytomas from Familial Birt-Hogg-Dub tumors