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In 2018, a study investigated the effect of PFD in paraquat-induced lung injury and fibrosis in mice and demonstrated that PFD ameliorates lung injury and fibrosis through inhibition of inflammation and oxidative stress, downregulation of profibrotic cytokines and enzymes for ROS production such as Nox1, Nox4, iNOS and through up-regulation of antioxidant enzymes such as SOD, catalase and GPx1 (Pourgholamhossein et al., 2018)

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The reasons why the patients were not linked to care were: poor adherence to treatment, not attending the medical visit, treatment rejection and patients that were lost by the system