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TRPM2 is also activated by ADPR upon stimulation with other extracellular stimuli including TNF in mouse cardiac ventricular myocytes (Roberge et al., 2014), amyloid -peptide (A) in rat striatal cells (Fonfria et al., 2005), and Zn 2+ in mouse microglial cells (Mortadza et al., 2017)

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Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

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