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Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever

Drusen accumulation between RPE and Bruchs membrane leads to RPE degeneration, photoreceptor death, and atrophy expansion (geographic atrophy in late stages)

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Results from the co-treatment with Fer1, a ferroptosis inhibitor, and ZVAD, an apoptosis inhibitor, indicate that RSL3 effects were reversed by Fer1 but not by anti-apoptotic ZVAD

A study of men on a long-term high-Cu diet found that high Cu intake significantly reduced the percentage of circulating neutrophils and serum IL-2R

This leads to less skin color, helping with melasma and hyperpigmentation